Yes, but don't forget... and maybe I'm wrong... but regardless of your layout choice (Table/Div) a good majority of your modules still export using tables which in my experience always blows a Pure CSS skin all to heck.

Now, I'm not saying not to go PureCSS, I've got projects that I'm working on that use a pure method, but nothing that's production as the end result isn't "stable" enough at the moment. I'm not proud to say I still use tables heavily for production but for the time being, speed of production > pure CSS since most my customers want a website that's functioning and they want it yesterday. Now, should a client specifically state he/she wants / has a need for a pure CSS skin I would without a doubt put one into production but it would add to the overall development / debugging time involved (as cross-browser compatibility becomes way more unpredictable in my experience).

~SB