I agree with Tom. If you are looking at building a pretty big eComm site, ASPDNSF ML/DNN version might be the way to go. We need more people on this to get a better community started. I am just now setting up a site myself. Here is my logo set. http://www.uncommongames.com/UG_logo_Rev2.png

You can check out this site. It is one of the first large ML/DNN sites. www.zonediet.com The people at zone diet have gone through a couple of ML/DNN upgrades and they say it is very robust. Much better than they expected. But they do have a full development staff. Once you are on the site, look to the right and hit Products to get to their actual store. They are more about education on the front end with a soft sell, so you don't really see their eComm offering much until you hit Products.

I really depends on your budget and long term plans, and unfortunately, the price just went up $300 a couple of weeks ago.