This is just a guess, but my guess would be yes as long as both applications used different object qualifiers I don't see how it wouldn't work.  However I really don't see any advantage to this.  If it did work it might make maitnence a little tedious because if you where trying to edit something in the database for one of the applications you would have to remember what object qualifier you used and then find that specific table.  I personally think that it would be easier to use a different database for each installation. 

However I am curious to know if using a different object qualifier for both installations would work

Hope this helps

Mike

Hi Sandip,

Just to add to what the others have already offered... are you aware that DNN is capiable of hosting any number of portals in the same database instance?  These portals can be linked to individual domains (e.g.; www.domain1.com, www.domain2.com) and even individual paths on the same domain (www.domain.com/site1, www.domain.com/site2). 

Make sure you don't do more work than is necessary!

Brandon