you could do it if you would be able to run a web server and an sql server off a usb stick. so the issue is not if DNN can do it, but more if IIS/Cassini and SQL Server can do it. Cassini can run from a stick i think, and you could use an SQL Server Express user instance, however, SQL Server Express still needs to run, so you might need to run an installer of some kind

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Yes, I would want to be totally offline.  In my situation, I travel with work.  I often want to experiment/plan/proof-of-concept/learn a CMS.  If I want to demonstrate what I've done then I can do it on anyone's PC.  In my situation, it is also much easier if I can do it totally offline, rather than using a development environment  or sandbox online.  I don't want to install or run anything from my work laptop's OS.  And I don't want to lug around a personal laptop.  Using PortableApps and XAMPP, I can run Apache, MySQL, and PHP all from the USB stick and on any PC. (The full list is: Apache, MySQL, PHP + PEAR, Perl, mod_php, mod_perl, mod_ssl, OpenSSL, phpMyAdmin, Webalizer, Mercury Mail Transport System for Win32 and NetWare Systems v3.32, Ming, JpGraph, FileZilla FTP Server, mcrypt, eAccelerator, SQLite, and WEB-DAV + mod_auth_mysql.)

In my situation, I really don't need to 'publish' the content anywhere and don't want to install anything on the host PC.

Thus my question.  Sorry that I didn't clarify earlier.

Thanks again,
Andrew