Unlike your view and other controls for which you can disable "Supports Partial Rendering", your settings control gets dynamically loaded into the core module settings page, modulesettings.ascx which DOES have "Supports Partial Rendering" enabled. As you have found out, the button which triggers the file upload must cause a full postback and as a general rule cannot be located within an UpdatePanel. Note there is no problem having the FileUpload control located within the UpdatePanel.

One way around this is to register the button which triggers the file upload as a post back button. Assuming that btnUpload is a reference to this button, place the following code in the Page_Init handler:

If Framework.AJAX.IsInstalled Then
    Framework.AJAX.RegisterPostBackControl(btnUpload)
End If

If you do not have a separate button which triggers the file upload, but rely on the Update button in the core modulesettings.ascx to also perform the upload, there is still a way (although more of a hack) to register that button. I recall posting the solution to that case about a year ago but can't find it right off.

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Bill, WESNet Designs
Team Lead - DotNetNuke Gallery Module Project (Not Actively Being Developed)
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hi!!!  this problem pass me too, but I found  this solution

https://sites.google.com/site/lagater...

however don´t work , pliss help!!