I have IIS6,aspnet2,sqlexpress.  web.config has been modified correctly. turned on all debugging options with iis, permissions ARE set properly, even 'scarily' gave IUSR full permissions briefly.  But still I get the message below.  I can't figure out how to correct it.  Do I need to put web.config in the root directory (it IS in the dotnetnuke root directory).  any ideas?

Server Error in '/DotNetNuke' Application.

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Configuration Error

Description: An error occurred during the processing of a configuration file required to service this request. Please review the specific error details below and modify your configuration file appropriately.

Parser Error Message: An error occurred loading a configuration file: Failed to start monitoring changes to 'd:\inetpub\wwwroot\web.config' because access is denied.

Source Error:

[No relevant source lines]

Source File: d:\inetpub\wwwroot\web.config    Line: 0

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Version Information: Microsoft .NET Framework Version:2.0.50727.42; ASP.NET Version:2.0.50727.42

Okay another update:
  on the win2k3 server, I got the install to at least get to a little different point by giving the <siteroot> directory the same permissions as the virtual 'dotnetnuke' directory.  I had to uninstall asp.net_v_2.... and reinstall  asp_regiis didn't do it.
however... new thread started.

You need to give the 'NETWORK SERVICE' user the permission to read /write, not the IUSR_.... user.

It is stated in the installation documentation.

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Geert Veenstra