I logged on and tried to access my file manager with host and admin accounts and I am getting errors.
Interesting thing is there is no  E:\WebRoot\IntranetPortals\PROD1\Portals\1\Icons\ directory on the server, and only one other Site administrator besides myself.
My intranet site is at a loss until I can recover the file manager.  My Log shows these errors:

Module Load Exception
ModuleId: 378
ModuleDefId: 21
FriendlyName: File Manager
ModuleControlSource: Admin/Files/FileManager.ascx
AssemblyVersion: 03.03.05
PortalID: 1
PortalName: My Portal Name
UserID: 1
UserName: host
ActiveTabID: 63
ActiveTabName: File Manager
RawURL: /Default.aspx?tabid=63&error=Object+reference+not+set+to+an+instance+of+an+object.&content=0
AbsoluteURL: /Default.aspx
AbsoluteURLReferrer:
UserAgent: Mozilla/4.0 (compatible; MSIE 6.0; Windows NT 5.1; SV1; .NET CLR 1.1.4322; InfoPath.1; .NET CLR 2.0.50727)
DefaultDataProvider: DotNetNuke.Data.SqlDataProvider, DotNetNuke.SqlDataProvider
ExceptionGUID: 5906ba7d-f6d0-42e9-9f40-97314ab5e243
InnerException: Invalid file name for monitoring: 'E:\WebRoot\IntranetPortals\PROD1\Portals\1\Icons\'. File names for monitoring must have absolute paths, and no wildcards.
FileName:
FileLineNumber: 0
FileColumnNumber: 0
Method: System.Web.FileChangesMonitor.StartMonitoringPath
StackTrace:
Message: DotNetNuke.Services.Exceptions.ModuleLoadException: Invalid file name for monitoring: 'E:\WebRoot\IntranetPortals\PROD1\Portals\1\Icons\'. File names for monitoring must have absolute paths, and no wildcards. ---> System.Web.HttpException: Invalid file name for monitoring: 'E:\WebRoot\IntranetPortals\PROD1\Portals\1\Icons\'. File names for monitoring must have absolute paths, and no wildcards. at System.Web.FileChangesMonitor.StartMonitoringPath(String alias, FileChangeEventHandler callback) at System.Web.Caching.CacheDependency.Init(Boolean isPublic, Boolean isSensitive, String[] filenamesArg, String[] cachekeysArg, CacheDependency dependency, DateTime utcStart) at System.Web.Caching.CacheDependency..ctor(String[] filenames) at DotNetNuke.Common.Utilities.FileSystemUtils.GetFolders(Int32 PortalID) at DotNetNuke.Modules.Admin.FileSystem.FileManager.BindFolderTree() at DotNetNuke.Modules.Admin.FileSystem.FileManager.Page_Load(Object sender, EventArgs e) --- End of inner exception stack trace ---

Page Load Exception
AssemblyVersion: 03.03.05
PortalID: 1
PortalName: My Portal Name
UserID: 1
UserName: host
ActiveTabID: 63
ActiveTabName: File Manager
RawURL: /Default.aspx?tabid=63&error=Object+reference+not+set+to+an+instance+of+an+object.&content=0
AbsoluteURL: /Default.aspx
AbsoluteURLReferrer:
UserAgent: Mozilla/4.0 (compatible; MSIE 6.0; Windows NT 5.1; SV1; .NET CLR 1.1.4322; InfoPath.1; .NET CLR 2.0.50727)
DefaultDataProvider: DotNetNuke.Data.SqlDataProvider, DotNetNuke.SqlDataProvider
ExceptionGUID: 77a722fc-12ef-40a7-b4d2-b0485aad7800
InnerException: Object reference not set to an instance of an object.
FileName:
FileLineNumber: 0
FileColumnNumber: 0
Method: DotNetNuke.Security.Permissions.Controls.FolderPermissionsGrid.SaveViewState
StackTrace:
Message: DotNetNuke.Services.Exceptions.PageLoadException: Object reference not set to an instance of an object. ---> System.NullReferenceException: Object reference not set to an instance of an object. at DotNetNuke.Security.Permissions.Controls.FolderPermissionsGrid.SaveViewState() at System.Web.UI.Control.SaveViewStateRecursive() at System.Web.UI.Control.SaveViewStateRecursive() at System.Web.UI.Control.SaveViewStateRecursive() at System.Web.UI.Control.SaveViewStateRecursive() at System.Web.UI.Control.SaveViewStateRecursive() at System.Web.UI.Control.SaveViewStateRecursive() at System.Web.UI.Control.SaveViewStateRecursive() at System.Web.UI.Control.SaveViewStateRecursive() at System.Web.UI.Control.SaveViewStateRecursive() at System.Web.UI.Control.SaveViewStateRecursive() at System.Web.UI.Control.SaveViewStateRecursive() at System.Web.UI.Control.SaveViewStateRecursive() at System.Web.UI.Control.SaveViewStateRecursive() at System.Web.UI.Control.SaveViewStateRecursive() at System.Web.UI.Control.SaveViewStateRecursive() at System.Web.UI.Page.SavePageViewState() at System.Web.UI.Page.ProcessRequestMain() --- End of inner exception stack trace ---
Source:

Any help would be greatly appreciated.
Thanks...