Full trust allows ASP.NET applications to execute native code, to read from the Registry and Windows Event Log, and to read and write to files outside of the application’s virtual directory. Medium trust limits the set of operations allowed, it will place a number of restrictions on an application, including limiting the file access. Many DNN modules require Full trust environment  to function properly. All of our sites run in Full trust and from our research and experience we found that there is no reason to do otherwise. General consensus is that you should run DNN in Full trust environment if possible.

As for setting the trust level it depends on your server and hosting provider.
For example on our shared hosting plans on 2008 servers we only need to change the web config file, however on plans running windows 2005 or erlier this is not possible and we needed to move the site to a specific full trust server.

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WSI - DNN Gold Partner | WSI - Internet Marketing
Matt Jura - blog on design, web and DotNetNuke | Twitter @MattsDailyTweet

Hi Joe
Can we read up on this topic somewhere or get hold of the presentations. It looks as the opinion is split on this one, MItchel Sellers and other valued community members seem to advocate the opposite.

I know that in the past the core DNN had problems with Medium trust (it was a while back) and it would be interesting to see your take on the subject in more depth.

As they say, every day is a school day :)

 

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WSI - DNN Gold Partner | WSI - Internet Marketing
Matt Jura - blog on design, web and DotNetNuke | Twitter @MattsDailyTweet