We are experiencing a similar problem. We are currently in the process of moving from Win2k3 to Win2k8.
Currently with IIS 6 we have our DNN instance running under a custom application pool with a domain account, without any problems.
BTW - we do this so we can use integrated authentication to access the database.
On Win2k8, I've managed to get some other standalone ASP.NET, ColdFusion etc sites running with an app pool with a domain user, but don't seem to be able to with DNN. I keep getting the following exception:
Description: An error occurred during the processing of a configuration file required to service this request. Please review the specific error details below and modify your configuration file appropriately.
Parser Error Message: Request for the permission of type 'System.Web.AspNetHostingPermission, System, Version=2.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089' failed. (E:\WebRoot\comwebdev.com.auckland.ac.nz\web.config line 88)
Source Error:
Line 86: <httpModules>
Line 87: <!-- add name="Authentication" type="DotNetNuke.HttpModules.AuthenticationModule, DotNetNuke.HttpModules.Authentication" / -->
Line 88: <add name="Compression" type="DotNetNuke.HttpModules.Compression.CompressionModule, DotNetNuke.HttpModules" /> Line 89: <add name="RequestFilter" type="DotNetNuke.HttpModules.RequestFilter.RequestFilterModule, DotNetNuke.HttpModules" />
Line 90: <add name="UrlRewrite" type="DotNetNuke.HttpModules.UrlRewriteModule, DotNetNuke.HttpModules" />
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It's from our development server and is just the standard install package for 4.9. I've set the app pool to allow 32bit apps & have set it to use the classic pipeline. Also the domain account has modify permissions from the root of the site. I've dealt with the hosting permission thing before, but that was only when trying to run a website from a network share & had to configure CAS to get around it.
I've searched and searched but don't seem to be able to find anything, any help would be much appreciated.
Cheers Wayne