I created a new Wiki (had to add a blank page using a text editor first though--no mention of this in the documentation.  I then created a 'door', and went to edit the first page.

Typed in some documentation, added a note, pressed save...and got this error:

Server Error in '/DNNC2L' Application.

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The resource cannot be found.

Description: HTTP 404. The resource you are looking for (or one of its dependencies) could have been removed, had its name changed, or is temporarily unavailable.  Please review the following URL and make sure that it is spelled correctly.

Requested URL: /DNNC2L/DesktopDefault.aspx

I'm quite possible doing something wrong--but I thought you folks would want to know...I'd love to know what I did wrong...just typed and added a 'note' (no documentation on what a 'note' does) and hit save.