Using DNN is definitely more complicated than creating a simple ASP.NET application. You might want to start playing around with web apps before digging into DNN because of this. If you're up for the challenge, tho, it's really not that much different. You'll just find some random oddities - like working with modules, for instance. Some concepts are tweaked to work with DNN's extensible architecture. Once you work in the environment for a while, you'll feel right at home, tho, and everything will become second nature. All I can say is, when you run into a snag, search Google for answers. 98% of the time, the problems users have (and post in the forums) aren't unique and have been answered at least 10x's before.

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Michael Flanakin | Microsoft Consulting Services
www.michaelflanakin.com