What page do you go to when this occurs?
Is this all you see, or do you see a partial rendering of the page, and part of it states an error has occured?

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Thank you,
James Campbell
MCP,MCSA,MCSE,Sec +
http://jamesecampbell.blogspot.com

Kristin;
By any chance to you get something like +Object+Not+Set+To+A+Reference+Of+An+Object appended to the URL in the browser address bar?
If you do not have any error appended on your URLwhat is in the URL in the browser address bar when this happens?

if, can you uncheck "Show Friendly HTTP error messages" and "Disable Script Debugging (Internet Explorer)" in IE under Tools --> Internet Options --> Advanced tab
Hopefully doing the above the rehitting the Default.aspx page will throw some errors that will help in finding a solution

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Ken Grierson
DotNetNuke Corporation
Test Lead