In most cases, the modifications necessary to web.config are done automatically in DotNetNuke versions 5.04.xx and later when the framework code senses a change to ASP.Net 4.0. One set of changes, however, was not automated until version 5.06.01. Please check that the core Captcha control (optionally used in site registration, blog, feedback, etc.) and the LinkClickHandler (used in many of the modules to handle link clicks including tracking the number of clicks) are working properly. You can also check the various handler registrations in the <system.webServer><handlers> section of web.config include the attribute

preCondition="integratedMode"

and NOT

preCondition="integratedMode,runtimeVersion2.0"

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Bill, WESNet Designs
Team Lead - DotNetNuke Gallery Module Project (Not Actively Being Developed)
Extensions Forge Projects . . .
Current: UserExport, ContentDeJour, ePrayer, DNN NewsTicker, By Invitation
Coming Soon: FRBO-For Rent By Owner