I would recommend contacting Sales@dnncorp.com and they can get you information about large installations of DNN.

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Chris Hammond
Former DNN Corp Employee, MVP, Core Team Member, Trustee
Christoc.com Software Solutions DotNetNuke Module Development, Upgrades and consulting.
dnnCHAT.com a chat room for DotNetNuke discussions

My previous business hosted about 350 parent portals on DNN. We moved from a single, multi web-head, load balanced single instance to multiple lower end appliances instances over time.

The primary drivers for this change had to do with overall performance, de-risking client introduced errors though silo'ing, a reduction in the complexity of our co-located infrastructure, a significant reduction in hardware costs over time ($800 Dell 1U boxes), the retirement of older infrastructure and finally better performance of each portal though segmentation of databases (fewer tabids, fewer shared modules, etc)

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Steven Webster
Manager, Community Platform
F5 Networks, DevCentral