Please ignore my last post, the following code works: protected void Page_Load(object sender, EventArgs e) { if (!IsPostBack) { LocalizationUtils.LocalizeGridView(gridProductList,LocalResourceFile); gridProductList.DataSource = DaoFactory.GetProductDao().GetProductsByPortalId(PortalId); gridProductList.DataBind(); } } public class LocalizationUtils { public static void LocalizeGridView(GridView gridView,string resourceFile) { string strKey = string.Empty; string strLocalizedText = string.Empty; foreach(DataControlField column in gridView.Columns) { strKey = column.HeaderText; if (strKey!=null && !strKey.Equals(string.Empty)) { strLocalizedText = Localization.GetString(strKey + ".Header", resourceFile); if (!strLocalizedText.Equals(string.Empty)) { column.HeaderText = strLocalizedText; } } } } }