Hello guys, I have two parent portals with for two domains. DomainA and DomainB I need to send users notifications according to activity in particular portal. e.g. if user get the new role in DomainA he/she should notification from mailer@domainA.com. I can set up only host email for sending notifications. So if user in DomainB get notification it is again from mailer@DomainA.com 

Is there any chance to set up mailer for every portal different?

Thanks

Yes and this is problem. The email is being sent from email in SuperUser (host) profile. This is for ALL portals the same email. I have one host(superUser) user. Can DNN send the notification for every portal? e.g. from portal's admin profile?

This is in "User Accounts" module - Adding or Removing user role for user send the email notification.