I am installing DNN 3.2.2 at my host (eNom) on a domain (www.domain.com) with the application pointed to the root of the DotNetNuke folder.  The install runs fine and I get no error messages.  However, when I try to go to the portal, it cannot get the settings.  It appears that the PortalAlias is not set for my domain.  I manually added an entry for PortalID 0 with a value of www.domain.com.  Firefox then throws an error that it cannot redirect in a way that will complete its request (IE goes into a constant loop). 

I am going to rebuild the installation, but am guessing that I will run into the same issue.  Has anyone else run into something similar?  Any ideas how to resolve it?

Thanks for the response Cathal.  The issue is that I cannot access the site due to a portal not configured to work on www.mydomain.com.  It does not appear that DNN knows which portal to pull based on the alias.  Here is the .NET error.

Server Error in '/DotNetNuke' Application.

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Object reference not set to an instance of an object.

Description: An unhandled exception occurred during the execution of the current web request. Please review the stack trace for more information about the error and where it originated in the code.

Exception Details: System.NullReferenceException: Object reference not set to an instance of an object.

Source Error:

An unhandled exception was generated during the execution of the current web request. Information regarding the origin and location of the exception can be identified using the exception stack trace below.

Stack Trace:

[NullReferenceException: Object reference not set to an instance of an object.] DotNetNuke.Entities.Portals.PortalSettings.GetPortalSettings(Int32 TabId, PortalAliasInfo objPortalAliasInfo) +114 DotNetNuke.Entities.Portals.PortalSettings..ctor(Int32 tabId, PortalAliasInfo objPortalAliasInfo) +93 DotNetNuke.HttpModules.UrlRewriteModule.OnBeginRequest(Object s, EventArgs e) +3757 System.Web.SyncEventExecutionStep.System.Web.HttpApplication+IExecutionStep.Execute() +60 System.Web.HttpApplication.ExecuteStep(IExecutionStep step, Boolean& completedSynchronously) +87