Specifically the Mac issue was in prior version of Solpart - which at the time was advertised as Mac compliant and didn't render on any Mac browsers. I agree this issue has improved substantially. But at the time it was a deal breaker for almost all of my clients that had to be overcome.
Jon - I think you were the one who posted regarding the css issue on the ASPNet forums. I wanted to address some of the points you brought up.
If I remember right - you stated you couldn't justify the trouble of doing a css layout when you can basically bang one out in tables (without hacks, etc..) in much less time.
I agree with your frustration with css layouts being difficult. What I've found (and it's rather humbling) is that I've had to go re-learn html and css from the ground up. As I've come through that process I've found that once you know the browser differences and a few (minimal) hacks, it's really quite easy. Almost as easy as html.
It was almost more than I cared to bother with to learn css layout techniques. My clients have been the driving force. They simply have demanded it. With Zeldman's css evism movement taking hold - it's going to become more and more an issue.
What I did find (much to my suprise) was an amazing speed difference in css based designs. Even partially css driven DNN skins seem to render much faster on the page - leading to greater client satisfaction. This is important when you're toting around 70k of Solpart's javascript on every page (and postback). I realize compression helps - but it's not always possible with certain modules.
Regardless of css driven design or not - what we're after (or I'm after) is valid xhtml (which keeps getting confused with css driven design). People can keep using table driven skins all day long - but I feel the core should generate valid xhtml markup that passes w3c standards. That's what my clients (more very day) are seriously demanding.