Trying to upload in File Manger and receive this error:
"The underlying system threw an exception. The file has not been..."

When trying to use the edit feature and upload an image we have a serious issue.  We click on the "Image Manager" and the new popup window appears.  However there is nothing in the panes.  The icons such as "Back", "Forward", "Refresh", "New Folder", "Delete" and all of the others do appear but none of them work.  This is something that just started.

When going into File Manager I right clicked on "Root" and can choose:
Create Folder
Refresh Folder
View Folder Properties

If I just click on it and choose the Refresh options I can choose:
Refresh
Sync This Folder
Sync This Folder & Subfolders

Just a quick note.  I am not able to delete, rename or create anything in file manger.  This is only happening to this one dedicated DNN install. Other DNN installations on the server are fine.  This only started happening the other day.

DNN 07.04.00 (353)
Windows 2008 R2
IIS 7.5.7600.16385
.NET 4.0

---------------------------------------------------  EVENT VIEWER LOG ----------------------------------------------------

AbsoluteURL:

DefaultDataProvider:DotNetNuke.Data.SqlDataProvider, DotNetNuke

ExceptionGUID:ea834401-b2e0-48d4-9f12-0e59db2bdd7f

AssemblyVersion:

PortalId:-1

UserId:-1

TabId:-1

RawUrl:

Referrer:

UserAgent:

ExceptionHash:jjpDcOTtuZN1LQtxD0+NJQ==

Message:Deleted 42 files, however, some files are locked. Could not delete the following files: C:\Inetpub\vhosts\KirbySalesInc.com\httpdocs\Portals\0-System\Cache\Pages\480_12501F292E5A603685E3125A20F9FDC5BC468018D1CD219CABAB93D3EFC7C5A9.data.resources;C:\Inetpub\vhosts\KirbySalesInc.com\httpdocs\Portals\0-System\Cache\Pages\481_12501F292E5A603685E3125A20F9FDC5BC468018D1CD219CABAB93D3EFC7C5A9.data.resources;C:\Inetpub\vhosts\KirbySalesInc.com\httpdocs\Portals\0-System\Cache\Pages\482_12501F292E5A60368

StackTrace:

   at DotNetNuke.Services.ModuleCache.FileProvider.PurgeExpiredItems(Int32 portalId)
   at DotNetNuke.Services.ModuleCache.PurgeModuleCache.DoWork()

InnerMessage:

InnerStackTrace:

Source:DotNetNuke

FileName:

FileLineNumber:0

FileColumnNumber:0

Method:

Server Name: real

---------------------------------------------------  EVENT VIEWER LOG ----------------------------------------------------

THREAD ID:7

TYPE:DotNetNuke.Services.ModuleCache.PurgeModuleCache, DotNetNuke

EXCEPTION:(TRUNCATED TO 500 CHARS): Deleted 42 files, however, some files are locked. Could not delete the following files: C:\Inetpub\vhosts\KirbySalesInc.com\httpdocs\Portals\0-System\Cache\Pages\480_12501F292E5A603685E3125A20F9FDC5BC468018D1CD219CABAB93D3EFC7C5A9.data.resources;C:\Inetpub\vhosts\KirbySalesInc.com\httpdocs\Portals\0-System\Cache\Pages\481_12501F292E5A603685E3125A20F9FDC5BC468018D1CD219CABAB93D3EFC7C5A9.data.resources;C:\Inetpub\vhosts\KirbySalesInc.com\httpdocs\Portals\0-System\Cache\Pages\482_12501F292E5A60368

RESCHEDULED FOR:3/19/2015 8:03:26 AM

SOURCE:STARTED_FROM_TIMER

ACTIVE THREADS:0

FREE THREADS:1

READER TIMEOUTS:0

WRITER TIMEOUTS:0

IN PROGRESS:0

IN QUEUE:7

Server Name: real